Dr. Janne and the SU2C-American Cancer Society Lung Cancer Dream Team have been focused on treating lung cancer patients with mutant KRAS. In this new publication, they report that a subgroup of patients with mutant KRAS may benefit from drugs called MEK inhibitors, if these patients do not have as much of the non-mutant KRAS protein. This information is helpful in deciding what treatments can be used for certain patients with mutant KRAS.

Stand Up To Cancer (SU2C) and Cancer Research UK (CRUK) invite applications for the SU2C-CRUK Pediatric Brain Cancer Dream Team Translational Research Grant. The Dream Team will address critical problems in pediatric (age range up to 18 years) brain cancer treatment and positively impact patients in the near future. The project will accelerate the development of prevention strategies, diagnostic approaches or treatments for pediatric brain cancers through investigation by a collaborative multidisciplinary, multi-institutional, transatlantic Dream Team. The project must be designed to accelerate therapeutic application to the clinic with patient involvement within 4 years of the grant term. Additionally, the project can address issues around late stage effects of pediatric brain cancer treatment. Proposed ideas should be based on perceived opportunities for success as well as high-priority areas with a critical patient need.

For more information on how to apply, please click here.

The Pancreatic Cancer Collective New Therapies Challenge represents a new, focused effort to increase the number of innovative and effective therapies to treat pancreatic cancer by support of pre-clinical and clinical development efforts. The Pancreatic Cancer Collective, a strategic collaboration of the Lustgarten Foundation and Stand Up To Cancer, will support collaborative, multi-disciplinary Teams to investigate novel or repurposed medicines, treatment strategies or technologies that have the potential to significantly impact pancreatic cancer patients in the near term.

For more information on how to apply, please click here.

The Stand Up To Cancer T-Cell Lymphoma Dream Team Translational Research Grant will fund a translational cancer research project focused on T-cell lymphoma that will address critical problems in patient care, including prevention strategies for those at risk, and deliver near-term patient benefit through investigation by a multidisciplinary, multi-institutional, collaborative Dream Team of expert investigators.

For more information on how to apply, please click here.

Ependymomas are a type of brain tumor that is notoriously difficult to treat. Scientists with the SU2C-St. Baldrick’s Foundation Pediatric Cancer Dream Team mapped out the genetic landscape of selected ependymomas to find targets for treatment and reported encouraging preliminary data on the identification of drugs that could have an impact on the tumors. Their report, with Michael D. Taylor, MD, PhD, a principal investigator with the Dream Team, as a senior author, is published in Nature, the highest-ranked journal of general and multidisciplinary science in the world. Our colleagues at the American Association for Cancer Research have prepared the attached Science Update on the paper, discussing its importance in the quest to find treatments for these tumors that occur most often in infants and children. 

Emily Whitehead, the little girl who was first person ever to receive the CAR-T treatment for leukemia, has been named one of the “ten people who mattered this year” by Nature, the world’s most influential journal of multidisciplinary science, marking FDA approval of the treatment, supported by SU2C research. “A young girl’s battle against leukemia inspired a new generation of cancer therapy,” Nature noted. Crystal Mackall, MD, co-leader of the SU2C-St. Baldrick’s Foundation Pediatric Cancer Dream Team, says the treatment is a “watershed.” Emily’s story is also told in this video from the 2014 SU2C telecast. 

Kara Bernstein, PhD, recipient of a 2016 Innovative Research Grant (IRG) from SU2C, is featured in a story on “Meet Three Women Breaking New Ground in Research” in the Media Planet supplement to USA TODAY on Education and Career News. Dr. Bernstein is at the University of Pittsburgh. She is using her IRG to study factors affecting predisposition to cancer.

Scientists supported by the Stand Up To Cancer-St. Baldrick’s Foundation Pediatric Cancer Dream Team have identified a promising new target for possible treatment of neuroblastoma, the most common cancer in infants. “We have built a strong foundation for developing a completely new and hopefully much less toxic treatment for neuroblastoma,” said John M. Maris, MD, a pediatric oncologist at Children’s Hospital of Philadelphia (CHOP) who is leader of the Dream Team and supervised a study published in Cancer Cell, a prestigious scientific journal. Crystal Mackall, MD, associate director of the Stanford Cancer Institute and co-leader of the Dream Team, is also a co-author of the paper. Maris, Mackall,and colleagues identified a protein that occurs on the surface of the tumor cells and then developed a combination of an antibody that zeroes in on the protein and a chemotherapy drug that attacks the DNA in the tumors while sparing healthy tissue. 

Hans Clevers, MD, PhD, leader of the SU2C-Dutch Cancer Society Tumor Organoids Dream Team, is featured in Science Magazine for his pioneering work on organoids, which are grown in the lab from small samples of cells taken from tumor tissue. They can be used to study patients’ tumors and to test new drugs. The Dream Team is focusing on colon cancer, breast cancer, and pancreatic cancer.

Scientists supported by Stand Up To Cancer have developed a test that spots tiny amounts of cancer-specific DNA in blood, allowing them to identify people with early-stage colorectal, breast, lung, and ovarian cancers. “This study shows that identifying cancer early using DNA changes in the blood is feasible and that our high accuracy sequencing method is a promising approach to achieve this goal,” says Victor Velculescu, MD, PhD, professor of oncology at the Johns Hopkins Kimmel Cancer Center and co-leader of the SU2C-Dutch Cancer Society Dream Team on Molecular Early Detection of Colorectal Cancer (MEDOCC). A report on the research, performed on blood and tumor tissue samples from 200 people with all stages of cancer in the U.S., Denmark and the Netherlands, appears as the cover story in the Aug. 16, 2017, issue of Science Translational Medicine, a major scientific journal.