DNA Repair Therapies for Ovarian Cancer Dream Team - Stand Up To Cancer

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SU2C–Ovarian Cancer Research Alliance–National Ovarian Cancer Coalition Ovarian Cancer Dream Team: DNA Repair Therapies for Ovarian Cancer

Grant Term: July 2015–June 2019

The SU2C-Ovarian Cancer Research Fund Alliance-National Ovarian Cancer Coalition Dream Team focused on developing new therapies that target DNA repair and applying them to a much larger group of women, beyond those with BRCA1 and BRCA2 mutations. By screening for inherited mutations in genes linked to DNA repair, the team worked to identify women at high risk for ovarian cancer for whom preventative measures may be lifesaving. With a combined focus on treatment and prevention, the program delivered near-term ovarian cancer patient benefit.

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ABOUT THIS TEAM’S RESEARCH

Ovarian cancer is usually diagnosed at an advanced stage, when it is hard to treat, and death rates are high. Cancers with certain types of DNA repair defects are responsive to targeted therapies, such as drugs called PARP inhibitors.

The Dream Team brought together internationally renowned experts to focus on developing new therapies that target DNA repair and on expanding the use of drugs called PARP inhibitor to a much larger group of women. In addition, by screening for inherited mutations in genes linked to DNA repair, the team worked to find ways to identify women at higher risk for ovarian cancer. The team took a three-pronged approach to its goals:

1. Identify ovarian cancers that are likely to respond to DNA repair therapies.
2. Evaluate, in three clinical trials, new drug combinations that may sensitize ovarian tumors to PARP inhibitors.
3. Develop web-based genetic testing and counseling strategies and test surgical prevention models.

MEET THE TEAM

The SU2C-Ovarian Cancer Research Fund Alliance-National Ovarian Cancer Coalition Dream Team brought together internationally renowned experts in the science of DNA repair, translational investigators, and clinicians, across six institutions.

Dream Team Members

Alan D. D’Andrea, MD
Dana-Farber Cancer Institute
Leader

Elizabeth M. Swisher, MD
University of Washington
Co-Leader

Gini F. Fleming, MD
The University of Chicago
Principal Investigator

Maria Jasin, PhD
Memorial Sloan Kettering Cancer Center
Principal Investigator

Scott H. Kaufmann, MD, PhD
Mayo Clinic, Rochester
Principal Investigator

Karen H. Lu, MD
MD Anderson Cancer Center
Principal Investigator

Jamie Crase
University of Washington
Advocate

Kathleen Gavin
Minnesota Ovarian Cancer Alliance
Advocate

Deborah Polinsky
SHARE Cancer Support
Advocate

Alexandra Feinstein
Dana-Farber Cancer institute
Project Manager

Donald Watson
Dana-Farber Cancer Institute
Project Manager

“We now see defective DNA repair as a more general vulnerability of ovarian cancer. We hope to extend the use of PARP inhibitors to many other patients and find combinations with other drugs that will be effective against ovarian cancer.”

Alan D. D’Andrea, MD
Dana-Farber Cancer Institute

TEAM PROGRESS UPDATES

Stand Up To Cancer’s research projects are designed to foster collaborative, swift translational research. The hallmarks of these efforts include rigorous application and selection procedures, sufficient funding to allow scientists to focus on the objectives of the grant, and reviews by senior scientists every six months. These reviews help the investigators capitalize on the latest findings, address potential roadblocks, and collaboratively evolve as the science requires. Please click on the link to see summaries of research results so far for the SU2C–OCRA–NOCC Ovarian Cancer Dream Team.

TEAM PROGRESS UPDATES

CLINICAL TRIALS REFERRALS

Cancer clinical trials allow researchers to study innovative and potentially life-saving new treatments. The goal is to find treatments that are better than what’s currently available; in fact, the therapies offered to today’s cancer patients were almost all studied and made possible by people participating in clinical trials. But many cancer clinical trials aren’t completed because not enough people take part.

At StandUpToCancer.org/ClinicalTrials, you’ll find clinical trial information, answers to common questions, and a free clinical trial finder tool.

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