The goal of this SU2C–Cancer Research Institute (CRI) Cancer Immunology Dream Team is to induce antitumor responses in immune cells called T cells. The team has taken two approaches to this: blocking the mechanisms that inhibit T cell activity (thereby allowing the T cells to expand, infiltrate, and kill cancer cells) and generating large quantities of T cells in the laboratory, enhancing their cancer-killing abilities, and then transferring them back to patients.