Prostate Cancer Precision Therapy Dream Team - Stand Up To Cancer

Dream Teams

Research  >  Research Portfolio  >  Dream Teams  >  Prostate Cancer Precision Therapy Dream Team

SU2C−Prostate Cancer Foundation Prostate Dream Team:
Precision Therapy of Advanced Prostate Cancer

Grant Term: August 2012−July 2016

Recent studies have demonstrated tremendous diversity in the genetic makeup of metastatic castration-resistant prostate cancer (mCRPC). The SU2C−Prostate Cancer Foundation (PCF) Prostate Dream Team is sequencing patient DNA and systematically comparing it with patient response to therapies. The aim is to identify biomarkers and predictors that will help physicians determine the best treatments for patients based on their molecular profiles.

Supported by:


The Precision Therapy of Advanced Prostate Cancer Dream Team hypothesizes that the molecular qualities of a patient’s CRPC can guide the doctor in choosing a “personalized” treatment. To advance this precision therapy, researchers have 1) implemented a multicenter study that systematically evaluates patients enrolling in 4 clinical trials for CRPC, 2) identified predictors of response, and 3) identified predictors of resistance.


The top scientists and researchers on the SU2C−PCF Prostate Dream Team come from a variety of backgrounds and disciplines, which leads them to great insights upon collaboration. Learn more about the SU2C−PCF Prostate Dream Team.

Dream Team Members

Arul M. Chinnaiyan, MD, PhD
University of Michigan

Charles L. Sawyers, MD
Memorial Sloan Kettering Cancer Center

Johann S. de Bono, MD, PhD
Institute of Cancer Research, Royal Marsden NHS Foundation Trust
Principal Investigator

Levi A. Garraway, MD, PhD
Dana-Farber Cancer Institute
Principal Investigator

Philip W. Kantoff, MD
Memorial Sloan Kettering Cancer Center
Principal Investigator

Peter S. Nelson, MD
Fred Hutchinson Cancer Research Center
Principal Investigator

Mark A. Rubin, MD
Weill Cornell Medicine
Principal Investigator

Woods Brown
University of Michigan

Thomas A. Farrington

Grant Gregory
Memorial Sloan Kettering Cancer Center

James Kiefert
Us TOO! International, Inc.

Stan Klein
Longwood Medical Area Prostate Cancer Support Group

Ian Liston

Douglas Pergament
University of Michigan

Karen Giles
University of Michigan
Project Manager

“Utilizing this Dream Team grant, we will be able to bring together great scientists and clinicians from around the world to join in the fight against metastatic prostate cancer. We hope this unique model of research will lead to patient benefit in the short term.”

Arul M. Chinnaiyan, MD, PhD
University of Michigan


Stand Up To Cancer’s research projects are designed to foster collaborative, swift translational research. The hallmarks of these efforts include rigorous application and selection procedures, sufficient funding to allow scientists to focus on the objectives of the grant, and reviews by senior scientists every six months. These reviews help the investigators capitalize on the latest findings, address potential roadblocks, and collaboratively evolve as the science requires. Please click below to see summaries of research results for the SU2C–PCF Prostate Dream Team.



Inherited DNA Repair Gene Mutations in Men with Metastatic Prostate Cancer
Chinnaiyan A, Garraway L, Sawyers C, de Bono J, et al. (2016)
New England Journal of Medicine 375(5):443-53.
Integrative Clinical Genomics of Advanced Prostate Cancer.
de Bono JS, Garraway LA, Sawyers CL, Chinnaiyan AM, et al. (2015)
Cell 161(5):1215-28.


Cancer clinical trials allow researchers to study innovative and potentially life-saving new treatments. The goal is to find treatments that are better than what’s currently available; in fact, the therapies offered to today’s cancer patients were almost all studied and made possible by people participating in clinical trials. But many cancer clinical trials aren’t completed because not enough people take part.

At, you’ll find clinical trial information, answers to common questions, and a free clinical trial finder tool.



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