The SU2C-Torrey Coast Foundation Gastroesophageal Cancer Dream Team Collective includes three Research Teams focused on bringing new therapies to clinical trials for the treatment of gastroesophageal cancer in diverse populations. This Collective aims to foster new and inclusive cancer research on the causes and treatments of gastroesophageal cancer, mentor a new generation of scientists focused on gastroesophageal cancer research, bring new treatments to the clinic, and provide medical professionals with tools and materials to better advocate for gastroesophageal cancer screening and treatment with their patients. This Research Team is specifically focused on creating novel therapeutic approaches for esophageal squamous cell carcinoma by eliminating an unfavorable metabolic environment for tumor growth.