The SU2C-CRUK Pediatric Cancer New Discoveries Challenge is a new, focused effort to spark novel approaches and new collaborations from investigators both within and outside the field of pediatric cancer research, with the ultimate aim of increasing the number of innovative and effective approaches to treating pediatric cancers. This program will support collaborative, multi-disciplinary, multi-institutional, trans-Atlantic Teams to pursue a transformative change in our understanding of the drivers of pediatric cancers and the development of novel or repurposed medicines, treatment strategies or technologies. With a clear and rational line of sight to the clinic, these projects will have the potential to significantly impact pediatric cancer patients, including teenagers and young adults.