Endometrial Cancers Convergence Research Team - Stand Up to Cancer
Help save a life

This holiday season, Mastercard is standing with us in the fight to end cancer as we know it. From now until December 31st, 2018, if you use a Mastercard to donate to Stand Up To Cancer, Mastercard will TRIPLE your gift, up to $300,000!

That’s triple the impact to support groundbreaking cancer research that will help save lives now!

$25 = $75
$50 = $150
$100 = $300
$250 = $750
GIVE FOR LIFE
For every $1 donated through StandUpToCancer.org with a Mastercard, Mastercard will donate $2, up to $300,000. Offer starts 12/14/18 at 12:01am ET and ends 12/31/18 at 11:59pm ET, or at the $300,000 max, whichever comes first.

Convergence Teams

Research  >  Research Portfolio  >  Convergence Teams  >  Endometrial Cancers Convergence Research Team

SU2C Endometrial Cancers Convergence Research Team:
Responders and Nonresponders to Endometrial Cancers With Mismatch Repair Deficiencies

Grant Term: January 2018–December 2020

This SU2C Endometrial Cancers Convergence Research Team is investigating why only half of all endometrial cancer patients with mismatch repair deficiencies respond to immunotherapy. The team is using patient biopsies from an ongoing clinical trial to figure out how to predict response and side effects and potentially design better immunotherapies for endometrial cancer patients. Mismatch repair deficiencies have been implicated in a wide variety of cancers, including some colorectal, stomach, small intestine, cervix, prostate, bile duct, and liver cancers, neuroendocrine tumors, and uterine sarcomas and ovarian cancers.

ABOUT THIS TEAM’S RESEARCH

It has been observed that cancers that harbor many mutations are more responsive to treatment with immunotherapies. Tumors that are DNA mismatch repair deficient (MMR-deficient) and microsatellite instability high (MSI-H) have more mutations than other cancers as two mechanisms for repairing DNA damage are malfunctioning. In MMR-deficient, MSI-high endometrial cancers, only about half of all patients respond to immunotherapy treatments, but it is not clear why.

To address this, the SU2C Endometrial Cancers Convergence Research Team is developing novel computational methods to compare biopsies from an ongoing clinical trial. The comparisons seek to identify the differences between patients who respond to treatment and those who do not. In addition, the team is searching for ways to predict who will develop side effects to immunotherapy so that these can be mitigated. Finally, the team is using this information to identify the neoantigens, or protein flags that are present on cancer cells, that are strongly recognized by the immune system.

Taken together, this information will help identify patients who will respond to anti-PD1 treatment, allow expected side effects to be mitigated in advance, and build a foundation for new treatment approaches for those who likely will not respond to the current standard of care.

MEET THE TEAM

The top scientists and researchers on the SU2C Endometrial Cancers Convergence Research Team come from a variety of backgrounds and disciplines, which leads them to great insights upon collaboration. Learn more about the SU2C Endometrial Cancers Convergence Research Team.

Team Members

Alessandro Santin, MD
Yale University School of Medicine
Team Leader

Ludmil Alexandrov, PhD
University of California, San Diego
Team Member

Stefania Bellone, PhD
Yale University
Team Member

Akiko Iwasaki
Yale University
Team Member

Alice Lustig
Stand Up To Cancer
Project Manager

TEAM PROGRESS UPDATES

Stand Up To Cancer’s research projects are designed to foster collaborative, swift translational research. The hallmarks of these efforts include rigorous application and selection procedures, sufficient funding to allow scientists to focus on the objectives of the grant, and six-monthly reviews by senior scientists. These reviews help the investigators capitalize on the latest findings, address potential roadblocks, and collaboratively evolve as the science requires. Please click on the link to see summaries of research results so far for the SU2C Endometrial Cancers Convergence Research Team.

TEAM PROGRESS UPDATES

PUBLICATIONS

This team started its work in January 2018. Links to publications will be posted when they are available.

CLINICAL TRIALS REFERRALS

Cancer clinical trials allow researchers to study innovative and potentially life-saving new treatments. The goal is to find treatments that are better than what’s currently available; in fact, the therapies offered to today’s cancer patients were almost all studied and made possible by people participating in clinical trials. But many cancer clinical trials aren’t completed because not enough people take part.

At StandUpToCancer.org/ClinicalTrials, you’ll find information and answers to common questions about clinical trials. Learn more and talk to your doctor to see if a clinical trial may be the best choice for you.

You can also connect with EmergingMed, a free and confidential clinical trial matching service that provides access to a vast database to help you identify the clinical trials that might be right for you or your loved one.

LEARN MORE