The SU2C–Dutch Cancer Society (DCS) Colorectal Cancer Early Detection Dream Team has set out to rework and improve the existing fecal immunochemical test (FIT) for colorectal cancer, which fails to detect approximately one-third of cancers and more than two-thirds of precancerous lesions. The team’s overarching goal is to move highly sensitive molecular testing for colorectal cancer to the next level so it can be regularly used in clinical settings.