Gastric Cancer Interception Research Team - Stand Up To Cancer

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SU2C Gastric Cancer Interception Research Team:
Early Detection and Interception of Diffuse and Intestinal Gastric Cancer

Grant Term: 2020–2023

Gastric (stomach) cancer is the third-leading cause of cancer death worldwide. New ways are needed to detect this cancer early, when it can be successfully treated. This research team is working to identify biomarkers, such as particular bits of DNA or cells shed from the tumor, that circulate in the blood system and indicate the presence of gastric cancer. The team has also developed a new detection technology using a pill-sized camera that can be swallowed by the patient and a marker that “lights up” cancer cells. This may enable researchers to capture images of stomach tissue at risk of developing cancer. If validated in a clinical trial, these methods will help doctors screen people in groups at risk of gastric cancer.

ABOUT THIS TEAM’S RESEARCH

More than 11,000 Americans die from gastric cancer every year, and it is much more prevalent in other countries, particularly in Asia. African-Americans and Hispanics are also at increased risk for gastric cancer, and it is more common in men than in women. In the United States, the rate of survival for gastric cancer five years after diagnosis is only 32 percent. This is largely because the disease is not usually detected until it is far advanced. Better means of early detection would save many lives.

The SU2C Gastric Cancer Interception Research Team is developing news ways to spot the cancer early, when it can be more successfully treated. This includes identifying bits of DNA and cells that break off from the tumors and circulate in the blood. Biomarkers found in animal studies will then be validated in human blood and tissue samples collected in the United States and in South Korea, where gastric cancer is far more common. If these biomarkers can be definitely tied to gastric tumors, they can be used to help detect the disease at an early stage. Scientists on the team have also developed a new imaging agent and a tiny, pill-sized camera that could perform imaging of stomach tissue at risk of developing cancer.

The team will validate its new methods in a clinical trial. Once these methods are available at the clinical level, doctors could use them to screen people in populations at risk of developing gastric cancer—such as people with a hereditary predisposition—and catch the problem early.

 

MEET THE TEAM

The top scientists and researchers on the SU2C Gastric Cancer Interception Research Team come from a variety of backgrounds and disciplines, which leads them to great insights upon collaboration. Learn more about the SU2C Gastric Cancer Interception Research Team.

Research Team Members

Andrew T. Chan, MD, MPH
Massachusetts General Hospital
Leader

Sandra Ryeom, PhD
University of Pennsylvania
Co-leader

Daniel Catenacci, MD
University of Chicago
Principal

Hyuk Lee, MD
Samsung Medical Center
Principal

Jeeyun Lee, MD
Samsung Medical Center
Principal

Yanghee Woo, MD
City of Hope Comprehensive Cancer Center
Principal

Sam Yoon, MD
Memorial Sloan Kettering Cancer Center
Principal

Marina Magicheva-Gupta
Massachusetts General Hospital
Project Manager

“We have been actively involved in developing new noninvasive endoscopic imaging techniques that can define areas of the stomach that are at high risk of developing cancer. We can also use this information to derive new blood-based biomarkers that can be used for early detection of stomach cancer.”

Andrew T. Chan, MD, MPH
Massachusetts General Hospital

TEAM PROGRESS UPDATES

Stand Up To Cancer’s research projects are designed to foster collaborative, swift translational research. The hallmarks of these efforts include rigorous application and selection procedures, sufficient funding to allow scientists to focus on the objectives of the grant, and reviews by senior scientists every six months. These reviews help the investigators capitalize on the latest findings, address potential roadblocks, and collaboratively evolve as the science requires. For the SU2C Gastric Cancer Interception Research Team, please click on the link below to see summaries of their research results so far.

TEAM PROGRESS UPDATES

PUBLICATIONS

This team started its work in January 2020. Links to publications will be posted when they are available.

CLINICAL TRIALS REFERRALS

Cancer clinical trials allow researchers to study innovative and potentially life-saving new treatments. The goal is to find treatments that are better than what’s currently available; in fact, the therapies offered to today’s cancer patients were almost all studied and made possible by people participating in clinical trials. But many cancer clinical trials aren’t completed because not enough people take part.

At StandUpToCancer.org/ClinicalTrials, you’ll find information and answers to common questions about clinical trials. Learn more and talk to your doctor to see if a clinical trial may be the best choice for you.

You can also connect with EmergingMed, a free and confidential clinical trial matching service that provides access to a vast database to help you identify the clinical trials that might be right for you or your loved one.

LEARN MORE

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